Rev-NIS

Description

Product name: Rev-NIS

Catalog#: 1399058

Organism:

Synonyms: Rev (11-20),

CAS NO.:

Sequence: ELLKAVRLIK

Modifications:

M.W:1182.50

M.F.:C55H103N15O13

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: Rev-NIS contained potent antifungal activities without hemolytic effects. Rev–NIS exerted antifungal activities by disrupting fungal membranes of Candida albicans and this result suggested a therapeutic potential as new antifungal agents. Rev is an essential regulatory protein for HIV-1 replication. Rev (11-20) is known as the significant region regarding the function of a nuclear entry inhibitory signal (NIS) of Rev. In this study, anticandidal effects and mechanism of action of Rev (11-20) were investigated. The result exhibited that Rev (11-20) contained candidacidal activities. To understand target site(s) of Rev (11-20), the intracellular localization of the peptide was investigated. The result showed that Rev (11-20) rapidly accumulated in the fungal cell surface. The cell wall regeneration test also indicated that Rev (11-20) exerted its anticandidal activity to fungal plasma membrane rather than cell wall. The fluorescent study using 1,6-diphenyl-1,3,5-hexatriene (DPH) further confirmed the membrane-disruption mechanism(s) of Rev (11-20). The present study suggests that Rev (11-20) possesses significant potential regarding therapeutic agents for treating fungal diseases caused by Candida species in humans.

Uniprot ID:

 

Usage: For Scientific Research Use Only, Not for Human Use.