SS-20

Description

Product name: SS-20

Catalog#: 1804023

Synonyms:

CAS NO.:

Sequence: Phe-D-Arg-Phe-Lys-NH2

M.W: C30H45N9O4

M.F.: 595.74

Purity: 95% by HPLC

Counter ion: Trifluoacetate

Format: Lyophilized powder

Description: The recent development of a series of mitochondrial targeted peptides that can inhibit MPT provides an opportunity to examine the potential of MPT inhibition as an approach to the treatment of PD. The SS (Szeto-Schiller) peptides are cell-permeable synthetic tetrapeptides that selectively partition to the inner mitochondrial membrane . Although these peptides carry 3+ net charge at physiologic pH, their mitochondrial uptake is not dependent on mitochondrial potential, and they do not cause mitochondrial depolarization. These mitochondrial-targeted peptides decrease mitochondrial ROS production, and inhibit mitochondrial swelling and cytochrome c release in isolated mitochondria. SS-20 at a dose of 4 mg/kg also produced complete neuroprotection against loss of dopaminergic neurons in the SNpc. The ability of SS-20 to protect against MPTP neurotoxicity in the whole animal and prevent MPP+-induced cytotoxicity suggests that the cytoprotective effects of these compounds may occur by mechanisms other than scavenging ROS.

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Usage: For Scientific Research Use Only, Not for Human Use.