$ 650.0
Quantity: 50 MG
Available on backorder
Description
Product name: Sulfated tetrapeptide
Catalog#: 1808138
Synonyms: Peptide-based heparin mimetics,
CAS NO.:
Sequence: SY(SO3)DY(SO3)
M.W:
M.F.:
Purity: 95% by HPLC
Counter ion: Trifluoacetate
Format: Lyophilized powder
Description: Molecules that mimic the sulfated glycosaminoglycan heparin and bind to heparin-binding growth factors would serve as important building blocks for synthetic biomaterials, e.g. to create a growth factor reservoir within a matrix. Peptide-based heparin mimetics would be particularly attractive, given the ease of peptide synthesis and modification. A sulfated tetrapeptide that fits this description and binds to vascular endothelial growth factor (VEGF) was discovered using a rationally-designed combinatorial approach.The binding affinity of the peptide for VEGF165 was ascertained by surface plasmon resonance and compared with the heparin mimic suramin; the peptide binds to VEGF165 100-fold stronger than the sulfonated compound. These results suggest that the identified peptide may be useful in biomaterial applications where binding of VEGF is desired.
Uniprot ID:
Usage: For Scientific Research Use Only, Not for Human Use.
